[主題] 離胺酸對貓皰疹病毒並無治療或預防效果？一篇新的Evidence-Base Reviews的結論

意外查到這一篇學術論文，是以Evidence-base的系統回顧分析先前的論文，結論讓我有點吃驚：「離胺酸對貓皰疹病毒並無治療或預防效果」
因為我帶貓咪去給醫生看，一般醫師都會說利用離胺酸來競爭精氨酸，治療貓咪上呼吸道的頭號殺手：皰疹病毒。但我意外在查醫學期刊時（我自己是西醫師），意外去查到獸醫學的新期刊發表文獻，是以實證基礎科學來分析過去認為離胺酸有效的論文，認為過去研究有瑕疵。所以結論竟然是叫：大家應該停止使用離胺酸，因為效果並不確定存在（當然也不否定）。隔行如隔山，這領域我不懂。不知道專家們怎麼看？

原論文出處：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647294/
Lysine supplementation is not effective for the prevention or treatment of feline herpesvirus 1 infection in cats: a systematic review
Abstract
Feline herpesvirus 1 is a highly contagious virus that affects many cats. Virus infection presents with flu-like signs and irritation of ocular and nasal regions. While cats can recover from active infections without medical treatment, examination by a veterinarian is recommended. Lysine supplementation appears to be a popular intervention (recommended by > 90 % of veterinarians in cat hospitals). We investigated the scientific merit of lysine supplementation by systematically reviewing all relevant literature.
Methods
NCBI’s PubMed database was used to search for published work on lysine and feline herpesvirus 1, as well as lysine and human herpesvirus 1. Seven studies on lysine and feline herpesvirus 1 (two in vitro studies and 5 studies with cats), and 10 publications on lysine and human herpesvirus 1 (three in vitro studies and 7 clinical trials) were included for qualitative analysis.
Results
There is evidence at multiple levels that lysine supplementation is not effective for the prevention or treatment of feline herpesvirus 1 infection in cats. Lysine does not have any antiviral properties, but is believed to act by lowering arginine levels. However, lysine does not antagonize arginine in cats, and evidence that low intracellular arginine concentrations would inhibit viral replication is lacking. Furthermore, lowering arginine levels is highly undesirable since cats cannot synthesize this amino acid themselves. Arginine deficiency will result in hyperammonemia, which may be fatal. In vitro studies with feline herpesvirus 1 showed that lysine has no effect on the replication kinetics of the virus. Finally, and most importantly, several clinical studies with cats have shown that lysine is not effective for the prevention or the treatment of feline herpesvirus 1 infection, and some even reported increased infection frequency and disease severity in cats receiving lysine supplementation.
Conclusion
We recommend an immediate stop of lysine supplementation because of the complete lack of any scientific evidence for its efficacy.

這篇文章被編輯了 2 次. 最近一次更新是在 7/3/18 12:47 PM

是看Journal of Feline Medicine & Surgery 嗎@@?

我自己有在寵物界工作過也有去當義工幫忙照顧病毒感染的貓
離胺酸確實是有用的當然還要看當下貓隻的身體健康狀況如何

貓皰疹病大部分開始都從眼鼻開始我們在照顧的過程中都會投入高單位的離胺酸
通常在2~3天貓的病情狀況會獲得緩解

對一些貓皰疹病嚴重到沒有食慾的貓在照顧上也會用灌食加上離胺酸通常會在4-6天左右慢慢緩解病情狀況

至於預防麻.....

有些貓的體質本來就是不太好的就算固定吃離胺酸也有可能會復發也是真的

(治療過程還是需要配合獸醫師開立的抗生素眼藥水/抗生素用藥...等)

請問身為西醫師的看法呢???
人的皰疹病毒問題，在國外是不是有也會有提到可補充離胺酸控制???

dasein79 wrote:意外查到這一篇學術論文，是以Evidence-base的系統回顧分析先前的論文，結論讓我有點吃驚：「離胺酸對貓皰疹病毒並無治療或預防效果」
因為我帶貓咪去給醫生看，一般醫師都會說利用離胺酸來競爭精氨酸，治療貓咪上呼吸道的頭號殺手：皰疹病毒。但我意外在查醫學期刊時（我自己是西醫師），意外去查到獸醫學的新期刊發表文獻，是以實證基礎科學來分析過去認為離胺酸有效的論文，認為過去研究有瑕疵。所以結論竟然是叫：大家應該停止使用離胺酸，因為效果並不確定存在（當然也不否定）。隔行如隔山，這領域我不懂。不知道專家們怎麼看？

這篇文章被編輯了 1 次. 最近一次更新是在 7/3/18 11:04 PM